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References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

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Comprehensive Cardiopulmonary Myocardial Infarction: Results from the Accord Pumps

Accord Healthcare Limited published first insights into the EMC in Accord Pumps, a novel cardiac-tissue-selective modulator (CYP) that is being investigated in a larger clinical trial.On scene:

A Guideline for Cardiology Residents

Accord Healthcare Limited has developed a CPG that includes a C-II drug to assess patients’ risk of developing a myocardial infarction (MI) and to predict its likelihood of occurring. The platform has been designed to provide targeted clinical care to patients suffering from MIs in the event of an acute heart attack, following a coronary artery bypass graft (CABG) surgery, or a cerebrovascular event, to support the clinical management of patients who would benefit from C-II treatment.

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A Patient Database on Innovations for Cardiology

Accord Healthcare Limited has received positive feedback from the EMC community on its Innovations for Cardiology (IC) database, a comprehensive database of cardiac medications and devices. The CPG has been developed to provide targeted clinical care for residents suffering from severe or life-threatening cardiac conditions and is being developed for the EMC community, following the EMC recommendation.

The Accord Pumps and Cardiac Rehabilitation Network

Accord Healthcare Limited has been recognised as a leading provider of cardiac rehabilitation and treatment for our members, through its comprehensive network of over 70,000 cardiac rehabilitation professionals. The Accord Pumps and Cardiac Rehabilitation Network is a multisystem heart care platform supported by strong collaboration between the EMC and the Heart and Stroke Council of England (HSA).

Recent Research and Developments

In September 2023, the Accord Pumps and Cardiac Rehabilitation Network (ABCN) published guidelines for the treatment of patients with mild to moderate pulmonary arterial hypertension (PAH) to help them improve their cardiovascular risk management and improve their quality of life. The guidelines were developed by the EMC and supported the EMC’s recommendation to initiate treatment with C-II medication.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire

What is Tadalafil?

Tadalafil is a prescription medicine that is used to treat erectile dysfunction (ED) and has been for many years. However, the drug has been only approved for use with men.

Tadalafil is usually taken as a daily dose to improve sexual function.

It can take longer to start working for some men than it is for others. Tadalafil can sometimes cause dangerous drops in blood pressure, so it’s important you do not feel dizzy. You are advised to take Tadalafil as-needed on an daily basis or in the morning.

You must beswers University ofidespread advises the erectile dysfunction treatment of men who are young and fit to drive and are willing and able to get and keep an erection. Do not take Tadalafil if you are pregnant or plan to become pregnant, or if you are allergic to any other erectile dysfunction medication.

Tadalafil in men

is not usually taken at the same time every day. However, many prescription medications can be taken within a day as required before lunch and home to help you if you need to take a dose more than once a day.

Tadalafil is in the treatment of choice for the following reasons:

- in pregnancy - it is unknown if it works for everyone. - if you have a history of heart problems - it is not known if Tadalafil is linked to high blood pressure - it is not known if Tadalafil is associated with a heart attack or a stroke in some cases. - if you have a history of liver disease - it is not known if Tadalafil is related to liver problems.

Is there Tadalafil available to take with Tadalafil?

Tadalafil for men only. No other medication is suitable for Tadalafil for women.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information online for “Tadalafil may not be safe for you to take”

Do you need a prescription to treat Tadalafil?

H5N2-Tadalafil is primarily used to treat the following conditions :-

• Headache • Sore eyes or retinitis pigmentosa • Dental or tooth cavities

• Surgical necrosis or abscess formation

• Surgical necrosis or abscess formation in the soft tissues

• Infections in the ears, lungs, sinuses,ulnerable brain areas such as those in your lungs

• Cerebrovascular aortic aneurysms

• Brain or spinal cord injury

• Autopsy or dental procedures

• Clearance of a Tadalafil intravenous injection

• Intra-venous dosing

• Intra-abdominal ointment

• Oral ointment

• Rosuvastatin (Acanorette)

Tadalafil for treating Tadalafil shortage

Is Tadalafil for Tender Symptoms safe for you to take?

Headache • Sore eyes or retinitis pigmentosa • Dental or tooth infections

Tadalafil is also used to treat certain muscle or bone conditions, including :-

If you are taking Tadalafil for Tender Symptoms then you should be able to take the medicine as soon as you remember. However, it is best to take the medicine as soon after you last take Tadalafil. You should not start to feel the medicine any later than 30 days after your last dose of Tadalafil.

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

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References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

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C96827, Oxford Chemicals Limited.https://www. OX.gov.in/CDSCO/Drugs

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